WebAug 23, 2024 · 4. Sulfonylureas are different from metformin. Metformin is a first-choice medication for most people with Type 2 diabetes. It works differently than sulfonylureas. Metformin's main job is to help make your body more sensitive to insulin. It also helps minimize how much sugar is absorbed into your bloodstream and how much sugar your … WebMay 1, 2001 · Glyburide/Metformin: ... Metformin is unusual among the oral antidiabetic drugs in that therapy has been associated with a lack of weight gain and even weight loss in some overweight patients. 16 ...
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